Integrative approaches generate insights into the architecture of non-syndromic cleft lip ± cleft palate
نویسندگان
چکیده
منابع مشابه
Cleft Lip and Cleft Palate
Cleft lip (cheiloschisis) and cleft palate (palatoschisis) can occur individual or together. Individuals with CLP may experience problems with feeding, speaking, hearing and social integration that can be corrected to varying degrees by surgery, dental treatment, speech therapy and psychological intervention. In India over 35,000 babies per year are affected. This review signifies the etiologic...
متن کاملEvaluating SKI as a candidate gene for non-syndromic cleft lip with or without cleft palate.
Non-syndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common of all congenital malformations and has a multifactorial etiology. Findings in mice suggest that the v-ski sarcoma viral oncogene homolog (SKI) gene is a candidate gene for orofacial clefting. In humans, a significant association between rs2843159 within SKI and NSCL/P has been reported in patients from the ...
متن کاملVariation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate.
Non-syndromic cleft lip with or without cleft palate (NSCLP) is a common birth defect. Genetic and environmental factors have been causally implicated and studies have begun to delineate genetic contributions. The Wnt genes are involved in regulating mid-face development and upper lip fusion and are therefore strong candidates for an etiological role in NSCLP. Furthermore, the clf1 region in A/...
متن کاملGenetics of cleft lip and palate: syndromic genes contribute to the incidence of non-syndromic clefts.
Clefts of the lip and/or palate (CL/P) are among the most common birth defects worldwide. The majority are non-syndromic where CL/P occurs in isolation of other phenotypes. Where one or more additional features are involved, clefts are referred to as syndromic. Collectively CL/P has a major clinical impact requiring surgical, dental, orthodontic, speech, hearing and psychological treatments or ...
متن کاملCleft lip and palate.
Author Disclosure Dr Abbott has disclosed no financial relationships relevant to this article. This commentary does not contain a discussion of an unapproved/ investigative use of a commercial product/ device. Editor’s Note: In the recently published article “Causal Attributions of Cleft Lip and Palate Across Cultures” (Cleft Palate Craniofac J. 2013;50[6]:655–661), the authors state that, acro...
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ژورنال
عنوان ژورنال: Human Genetics and Genomics Advances
سال: 2021
ISSN: 2666-2477
DOI: 10.1016/j.xhgg.2021.100038